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    Glossary Cell cycle inhibitor

    molecule that halts or slows down cell division

    A cell cycle inhibitor, also known as a cell cycle suppressor or cell cycle regulator, is a molecule that can halt or slow down the process of cell division. These inhibitors play a crucial role in controlling cell growth and ensuring that cells do not divide uncontrollably, which is important for preventing conditions like cancer. For example, proteins like p21 and p27 are well-known cell cycle inhibitors that can stop the cell cycle at specific checkpoints, allowing for DNA repair or triggering cell death if the damage is irreparable.

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    1. Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells Genes & Diseases · 2020 · 10 citations
    2. PLA2R1 Overexpression Causes Podocyte Injury by Inhibiting the Cell Cycle: A Clinical Cross-Sectional Investigation and Cellular Study International Journal of Nephrology and Renovascular Disease · 2025
    3. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    4. 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia Journal of Investigative Dermatology · 2023
    5. Immune cell regulation of the hair cycle Experimental Dermatology · 2020 · 27 citations
    6. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012 · 68 citations
    7. Editorial: Stem cell exhaustion in aging Frontiers in Aging · 2024 · 13 citations
    8. Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    9. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    10. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    11. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012 · 321 citations
    12. Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors Science · 2001 · 153 citations
    13. miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4 Cells · 2025 · 4 citations
    14. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    15. Controlling the stem cell niche: right time, right place, right strength BioEssays · 2005 · 29 citations
    16. 5-Fluorouracil induces hair loss by inhibiting β-catenin signaling and angiogenesis Chemico-Biological Interactions · 2025
    17. FGF signaling for hair cycle resting phase alleviates radiation alopecia Journal of Dermatological Science · 2016 · 1 citations
    18. 502 The stress-responsive secretory protein adrenomedullin 2 potently induces cell cycle arrest and apoptosis in human hair follicles Journal of Investigative Dermatology · 2024
    19. Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling Biocell · 2023
    20. Cedrol restricts the growth of colorectal cancer <i>in vitro</i> and<i> in vivo</i> by inducing cell cycle arrest and caspase-dependent apoptotic cell death International Journal of Medical Sciences · 2022
    21. 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia Journal of Investigative Dermatology · 2022 · 1 citations
    22. 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle 2023
    23. Intensive stress impedes hair follicle growth through triggering cell cycle arrest of hair follicle stem cells The FASEB Journal · 2025
    24. Coordinated inhibition of SOX9 and cell cycle progression by microRNA-200 restricts sebaceous gland fate specification 2026 · 1 citations
    25. B-219 Apoptotic effect and cell cycle arrest by Juniperus communis extract on oral cancer Clinical Chemistry · 2025
    26. Cyclin-dependent kinase inhibitors, p21waf1/cip1 and p27kip1, are expressed site- and hair cycle-dependently in rat hair follicles Journal of Dermatological Science · 2001 · 9 citations
    27. 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis European journal of pharmacology · 2016 · 18 citations
    28. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013 · 52 citations
    29. Small RNAs Loom Large During Reprogramming Cell stem cell · 2011 · 18 citations
    30. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019 · 10 citations