Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells

    January 2025 in “ Foods ”
    Hee-Jeong Ryu, Syng‐Ook Lee
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    TLDR Mealworm protein helps fat cell development and may aid in metabolic health and hair growth.
    This study explores the impact of mealworm-derived protein hydrolysates (Fh-T) on adipogenic differentiation in 3T3-L1 cells, particularly during the mitotic clonal expansion phase. Fh-T significantly promotes adipocyte differentiation and enhances adiponectin expression without cytotoxicity at concentrations of 200-800 μg/mL. It upregulates key adipogenic transcription factors like PPARγ and C/EBPα and increases the expression of adipocyte markers. Fh-T enhances adipogenesis when combined with MDI by promoting cell cycle progression, linked to increased C/EBPδ and decreased p27 expression. The study suggests Fh-T's potential in metabolic health management and as a bioactive ingredient in cosmeceuticals and regenerative therapies, including possible applications in hair growth.
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