TLDR MicroRNAs can reprogram cells into stem cells faster and more efficiently than traditional methods.
In 2011, studies by the Morrisey and Mori groups demonstrated that human and mouse somatic cells could be reprogrammed into induced pluripotent stem cells (iPSCs) using microRNAs (miRNAs) without ectopic protein expression. The Morrisey study used lentiviral expression of the miR302-367 cluster in fibroblasts, while the Mori group used a cocktail of seven miRNAs. These miRNA-based methods were more efficient and faster than traditional transcription factor-mediated reprogramming, suggesting miRNAs could replace transcription factors in reprogramming for regenerative therapies.
308 citations,
September 2010 in “Nucleic acids research” Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.
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September 2021 in “International Journal of Nanomedicine” Tiny particles called extracellular vesicles show promise for treating skin conditions and promoting hair growth.
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October 2022 in “Regenerative Therapy” New regenerative treatments for hair loss show promise but need more research for confirmation.
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April 2023 in “Cosmetics” Exosomes could be effective for improving skin health and treating skin diseases.
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28 citations,
April 2023 in “Stem cell research & therapy” Tiny vesicles from stem cells could be a new treatment for healing wounds.
