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GlossaryComplementary DNA (cDNA)

form of DNA synthesized from an mRNA template

Complementary DNA (cDNA) is a form of DNA synthesized from a messenger RNA (mRNA) template in a process called reverse transcription. This type of DNA is often used in gene cloning or as a probe in the study of gene expression because it represents only the expressed genes of an organism, excluding non-coding regions.

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Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations, December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

research The cDNA-Deduced Amino Acid Sequence for Trichohyalin, a Differentiation Marker in the Hair Follicle, Contains a 23 Amino Acid Repeat

39 citations, February 1990 in “The journal of cell biology/The Journal of cell biology”

Trichohyalin, a hair follicle protein, has a part with repeating patterns of 23 amino acids.

Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

research Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

13 citations, June 2007 in “Journal of Dermatological Science”

Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.

research Construction of a cDNA Library and Identification of Genes from Liaoning Cashmere Goat

6 citations, March 2014 in “Livestock science”

Researchers created a genetic library from a cashmere goat's skin and found new genes linked to hair growth.

research Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin

124 citations, November 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

research Discovery of Genes and Proteins Possibly Regulating Mean Wool Fibre Diameter Using cDNA Microarray and Proteomic Approaches

6 citations, May 2020 in “Scientific reports”

Researchers identified genes and proteins that may influence wool thickness in sheep.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations, June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

research Intermediate Filaments: Regulation of Gene Expression and Assembly

50 citations, June 1993 in “European journal of biochemistry”

Intermediate filaments are crucial for cell structure and function, regulated by specific genes and proteins.

research Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

14 citations, October 2000 in “Genomics”

Rat dermal papilla cells have unique genes crucial for hair growth.

research Identification of Androgen-Regulated Genes in SV40-Transformed Human Hair Dermal Papilla Cells

12 citations, May 2003 in “Journal of dermatological science”

Hsc70 protein may influence hair growth by responding to androgens.

research TR3 Is Preferentially Expressed by Bulge Epithelial Stem Cells in Human Hair Follicles

7 citations, January 2016 in “Laboratory Investigation”

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

research Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

6 citations, February 2013 in “Journal of Visualized Experiments”

The method quickly analyzes hair growth genes and shows that blocking Smo in skin cells stops hair growth.

research Skipping of Exons by Premature Termination of Transcription and Alternative Splicing Within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant

6 citations, June 2012 in “PloS one”

A new mRNA variant of the SCF gene in sheep skin produces a shorter, different protein.

research Cloning and Expression of Cellular Retinoic Acid Binding Protein I Gene in Inner Mongolian Cashmere Goats

1 citations, January 2012

The CRABP I gene in cashmere goats is highly conserved but has unique features at specific amino sites.

research Evaluation of Short-Term Hair Follicle Storage Conditions for Maintenance of RNA Integrity

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair follicles can be kept in RNAlater® at cool or room temperature for a week without harming RNA quality.

research Androgenic Alopecia: Characteristics and Perspectives

January 1992 in “Juntendo Medical Journal”

Male pattern baldness is mainly caused by a hormone called dihydrotestosterone (DHT), and drugs that can block this hormone might help prevent hair loss.

research Versican Expression by Dermal Papilla-Regenerated Hair Follicles: A Promising Tool for Hair-Regrowth Products

5 citations, May 2004 in “International Journal of Cosmetic Science”

Versican is important for hair growth and could help find new hair regrowth treatments.

research Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture

28 citations, March 2010 in “Histochemistry and cell biology”

Skin cells can help create early hair-like structures in lab cultures.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations, September 1999 in “The journal of cell biology/The Journal of cell biology”

K16 can partially replace K14 but causes hair loss and skin issues.

research A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia

26 citations, October 2002 in “Journal of Investigative Dermatology”

A specific gene mutation causes congenital hair loss.

research Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle

18 citations, July 2016 in “Genetica”

BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.

research Comparative Proteomics Indicates That Biosynthesis of Pectic Precursors Is Important for Cotton Fiber and Arabidopsis Root Hair Elongation

169 citations, September 2010 in “Molecular & cellular proteomics”

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.