Urtica Dioica Extract Downregulates the Gene Expression of 5α-Reductase Type II in HaCaT Cells: Possible Implications Against Androgenic Skin Diseases
January 2023
in “
PubMed
”
Urtica dioica 5α-reductase type II HaCaT cells androgenic skin diseases real-time reverse transcription quantitative polymerase chain reaction gene expression anti-androgenic activity cosmetic dermatology nettle extract 5α-RII skin cells androgenic skin conditions RT-qPCR anti-androgenic cosmetic skin treatments
TLDR Urtica dioica extract may help treat androgenic skin diseases by reducing a specific gene's activity.
The study investigates the effects of Urtica dioica (Ud) extract on the gene expression of 5α-reductase type II (5α-RII) in HaCaT skin cells, aiming to explore its potential against androgenic skin diseases. The researchers treated cultured HaCaT cells with Ud extract and performed real-time reverse transcription quantitative polymerase chain reaction analysis to measure gene expression. The results showed a statistically significant downregulation of 5α-RII gene expression (p=0.0021) in treated cells, with a fold change of 0.5873±0.0586 compared to untreated cells. This suggests that Ud extract has anti-androgenic activity and potential therapeutic applications in cosmetic dermatology for treating androgenic skin conditions.
