Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses various Wnt pathway modulators developed between 2014 and 2020, highlighting their potential as treatments for diseases like cancer and osteoarthritis, but reports no new clinical results.

This review assessed the potential of mesenchymal stem cell therapy to enhance burn wound healing, highlighting its capabilities in promoting angiogenesis, reducing inflammation, and regenerating damaged tissues, while identifying preclinical and clinical challenges that need addressing to optimize treatment outcomes.

This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.

This study found that knockdown of PCAT1 inhibited hair follicle regeneration in nude mice by disrupting the miR-329/Wnt10b axis and Wnt/β-catenin signaling, highlighting PCAT1's role in promoting follicle regrowth.

This review discusses the potential of cell-derived nanovesicles as innovative treatment strategies for hair growth and provides no new clinical results; the authors emphasize the need for further understanding of their mechanisms.

This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.

This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.

This review discusses various applications of CRISPR-based tools in cancer research, emphasizing their potential for investigating microRNA functions and developing microRNA-based therapies, despite challenges like off-target effects and delivery issues in using CRISPR/Cas9.

In this study, finasteride was found to enhance stem cell properties in dermal papilla cells, suggesting potential benefits for hair loss management and regenerative therapies.

This study concluded that hair-derived stem cells from older donors may offer a promising alternative for autologous corneal endothelial replacement, potentially benefitting patients of various age groups.

This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.

This review discusses current stem cell technologies, their potential therapeutic uses, and imaging techniques for tracking transplanted cells, without reporting new experimental results.

This review discusses the role of extracellular vesicles from specific skin cells in wound healing, emphasizing their potential in regenerative medicine and reporting no new experimental results.

In this study, researchers developed a new 3D skin equivalent assay using mouse epidermal and dermal cells that successfully regenerated organized hair follicles, outperforming a 2D model in hair follicle orientation and quantity, and enhanced hair growth when Wnt3a was added.

This review summarizes the characteristics of the peri-malignant melanoma stroma, indicating its potential role in early dermal metastatic migration and increased metastasis risk.

This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.

This study found that lncRNA-599547 positively regulates the expression of the Wnt10b gene by interacting with miR-15b-5p, enhancing the inductive property of dermal papilla cells in cashmere goats.

This study found that overexpression of R-spondin 3 in a mice model impaired hair morphogenesis and regeneration by reducing hair matrix progenitor cell proliferation, thus disrupting the Wnt pathway's regulation of stem cells.

This study suggests that CGE may enhance hair growth by activating β-catenin signaling pathways in human hair dermal papilla cells and promoting the anagen growth phase in mice.

This review discusses the role of nanoparticles in cancer diagnosis and treatment and outlines their potential to improve outcomes by reducing systemic toxicity and overcoming multidrug resistance, though it reports no new clinical results.

This study found that engineered skin substitutes made with skin-derived precursors and epidermal stem cells can regenerate hair follicles after grafting into nude mice.

This article describes how PESCADOR software assists in creating detailed biological pathway charts from PubMed abstracts, focusing on hair and breast development case studies without providing new clinical results.

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

This meeting in Heidelberg highlighted diverse contributions on stem cell research, including pre-clinical and clinical applications, but reported no new experimental results.

This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.

This review provides an in-depth analysis of the structure and function of c-kit activation, and its role in both normal physiological and pathological conditions, with no new research findings reported.

This study suggests that human dermal fibroblasts can be converted into dermal papilla cell-like cells using microencapsulation, which may facilitate hair follicle regeneration in mice without chemical or genetic reprogramming.

This study found that all-trans retinoic acid (ATRA) negatively affects hair growth by reducing goat dermal papilla cell viability and growth factor expression.

Different stem cells have benefits and challenges for tissue repair, and more research is needed to find the best types for each use.

This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.