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    Glossary Bulge Region

    specific area in hair follicle housing stem cells

    The bulge region is a specific area located in the outer root sheath of a hair follicle. It contains a reservoir of stem cells that are crucial for hair growth and regeneration. These stem cells can also contribute to the repair of the skin and other tissues, making the bulge region essential for both hair health and overall skin maintenance.

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    1. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles Differentiation · 1994 · 130 citations
    2. Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata 2010 · 20 citations
    3. Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation International journal of oncology · 2009 · 8 citations
    4. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    5. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    6. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    7. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020 · 1 citations
    8. Immune response involving the bulge region in addition to telogen conversion contributes to hair loss in a case of atypical drug-induced hypersensitivity syndrome The Journal of Dermatology · 2013 · 1 citations
    9. Abstract 4300: Constitutive activation of Stat3 increases hair follicle progenitor population at the expense of bulge region keratinocyte stem cells Cancer Research · 2010
    10. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations
    11. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients 2017 · 18 citations
    12. Autofluorescence in the Stem Cell Region of the Hair Follicle Bulge Journal of Investigative Dermatology · 2005 · 17 citations
    13. 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion Journal of Investigative Dermatology · 2019
    14. Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments Histochemistry and Cell Biology · 2010 · 28 citations
    15. Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells Dermatology · 2007 · 16 citations
    16. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles Laboratory Investigation · 2016 · 7 citations
    17. Hairy Math: Addition of Wnt-3a to Multiply Bulge Cells Journal of Investigative Dermatology · 2015
    18. The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice Journal of Investigative Dermatology · 1999 · 9 citations
    19. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000 · 1010 citations
    20. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations Journal of Clinical Investigation · 2011 · 178 citations
    21. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006 · 176 citations
    22. Hair follicle stem cells: Walking the maze European Journal of Cell Biology · 2007 · 165 citations
    23. Hair Follicle Stem Cells 2003 · 142 citations
    24. Developmental timing of hair follicle and dorsal skin innervation in mice Journal of comparative neurology · 2002 · 86 citations
    25. Neural Potential of a Stem Cell Population in the Hair Follicle Cell Cycle · 2007 · 80 citations
    26. A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004 · 61 citations
    27. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011 · 60 citations
    28. Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation Cancer research · 2009 · 49 citations
    29. Hair follicles, their disorders and their opportunities Drug Discovery Today: Disease Mechanisms · 2008 · 48 citations
    30. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle 2001 · 45 citations