Differential Distribution of the Epigenetic Marker 5-Hydroxymethylcytosine in Hair Follicle Stem Cells During Bulge Activation

    February 2019 in “ Journal of Cutaneous Pathology ”
    Danielle Leavitt, Michael Wells, Phammela Abarzua, Gëorge F. Murphy, Christine G. Lian
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    TLDR The marker 5-hmC changes in hair follicle stem cells when they start to grow.
    In 2019, researchers from Harvard College and Brigham and Women's Hospital investigated the role of the epigenetic hydroxymethylation marker, 5-hmC, in the activation of hair follicle stem cells. They found that the distribution of 5-hmC varied within the nuclei of CK15-positive stem cells in the bulge region of murine hair follicles during early anagen, a growth phase. This pattern was not seen in resting stem cells of telogen follicles, which did not express 5-hmC. Additionally, changes in 5-hmC reactivity in bulge stem cells were observed during early anagen phases induced in an organ culture model. These findings suggested that 5-hmC might play a dynamic role in bulge activation during anagen growth, laying the groundwork for further research into the epigenomic regulation of hair follicle stem cells.
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