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    Glossary 5-Hydroxymethylcytosine

    modified DNA base involved in gene expression regulation

    5-Hydroxymethylcytosine (5hmC) is a modified form of the DNA base cytosine, which plays a role in the regulation of gene expression. It is often found in the brain and other tissues, and its presence is associated with active DNA demethylation processes, which can influence cellular functions and development.

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    1. Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation Journal of Cutaneous Pathology · 2019 · 4 citations
    2. 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation 2021
    3. 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression 2020
    4. 570 DNA dioxygenases Tet1/2/3 control cell differentiation in the hair follicle keratinocytes via modulating the activity of BMP signaling pathway 2019
    5. Loss of TET2 Tips the Scales Toward Tumorigenesis 2022
    6. 506 Taxane chemotherapy promotes aging of human hair follicles and their stem cells Journal of Investigative Dermatology · 2024
    7. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    8. 573 Hair follicles employ a 2-dimensional healing strategy to repair 3-dimensional injuries 2019
    9. N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma Journal of Investigative Dermatology · 2023 · 11 citations
    10. Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells Medical Sciences · 2017 · 37 citations
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