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    Glossary 5-Hydroxymethylcytosine

    modified DNA base involved in gene expression regulation

    5-Hydroxymethylcytosine (5hmC) is a modified form of the DNA base cytosine, which plays a role in the regulation of gene expression. It is often found in the brain and other tissues, and its presence is associated with active DNA demethylation processes, which can influence cellular functions and development.

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    1. Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation Journal of Cutaneous Pathology · 2019 · 4 citations
    2. 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation 2021
    3. 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression 2020
    4. 570 DNA dioxygenases Tet1/2/3 control cell differentiation in the hair follicle keratinocytes via modulating the activity of BMP signaling pathway 2019
    5. Loss of TET2 Tips the Scales Toward Tumorigenesis 2022
    6. 506 Taxane chemotherapy promotes aging of human hair follicles and their stem cells Journal of Investigative Dermatology · 2024
    7. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    8. 573 Hair follicles employ a 2-dimensional healing strategy to repair 3-dimensional injuries 2019
    9. N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma Journal of Investigative Dermatology · 2023 · 11 citations
    10. Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells Medical Sciences · 2017 · 37 citations
    11. 803 Taxane chemotherapy induces epigenetic changes and premature senescence in human scalp hair follicles Journal of Investigative Dermatology · 2024
    12. 574 Murine sebaceous gland homeostasis requires intact cutaneous innervation in a hair cycle-dependent context 2019
    13. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    14. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    15. Comprehensive Administrative and Engineering Strategies for Radiation Protection and Occupational Health Safety Clinical and Medical Engineering Live · 2025
    16. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    17. Hypothalamic DNA methylation in rats with dihydrotestosterone‐induced polycystic ovary syndrome: effects of low‐frequency electro‐acupuncture Experimental physiology · 2018 · 18 citations
    18. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation Science advances · 2023 · 3 citations
    19. Volatile organic compounds: A proinflammatory activator in autoimmune diseases Frontiers in Immunology · 2022 · 18 citations
    20. Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma EBioMedicine · 2021 · 7 citations
    21. Dynamics and Epigenetics of the Epidermal Differentiation Complex Epigenomes · 2024
    22. Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche Cell stem cell · 2011 · 695 citations
    23. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    24. Non-viral delivery of the CRISPR/Cas system: DNA<i>versus</i>RNA<i>versus</i>RNP Biomaterials Science · 2022 · 21 citations
    25. Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models Frontiers in Oncology · 2024 · 17 citations
    26. Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery BMC Genomics · 2024 · 9 citations
    27. Antioxidant Natural Plant Constituents for Diabetic Wound Repair MedComm – Biomaterials and Applications · 2025 · 2 citations
    28. The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions Aging and Disease · 2026
    29. The Pathobiology of Skin Aging American Journal Of Pathology · 2020 · 122 citations
    30. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations