April 2024 in “Bioactive materials” This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.
March 2019 in “SLAS TECHNOLOGY” This study found that MSN-ceria nanomaterial accelerates cutaneous wound healing in rat models by reducing ROS levels and promoting collagen deposition, leading to improved tissue regeneration without significant scarring.
October 2022 in “Frontiers in Bioengineering and Biotechnology” This study demonstrated that in a mouse model of androgenic alopecia, PLGA-DUT/siAR@DPCM nanoparticles effectively delivered drugs to hair follicles, suppressed androgen-related targets, promoted cell proliferation, and showed significant therapeutic effects with minimal adverse effects, suggesting their potential for clinical application.
This study explored Black Sea shark liver oil-based emulgels, finding that the addition of borage oil (Gel 2) enhanced the anti-inflammatory and wound healing properties compared to shark liver oil alone (Gel 1) and a reference diclofenac gel, suggesting promising eco-friendly applications in dermatocosmetics.
February 2025 in “Advanced Composites and Hybrid Materials” This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.
12 citations
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February 2019 in “Skin research and technology” This study found that white hair fibers have lower lipid content and different water absorption dynamics compared to brown hair fibers, suggesting differences in their barrier functions.
February 2025 in “Biomimetics” This study developed a novel hair-straightening shampoo incorporating a polyphenol–inorganic sulfate redox agent, finding that it effectively straightens hair while enhancing strength and reducing damage due to its protective polyphenol coating.
October 2023 in “Biomimetics” This study developed a biocompatible hair-dyeing technology using a dark polyphenol complex, which demonstrated effective hair coating, improved mechanical strength, and strong antioxidant properties while maintaining high cell viability.
3 citations
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May 2024 in “Biomimetics” This narrative review examines the structure-function relationship in bioactive biopolymers used to promote healing in chronic wounds, emphasizing diabetic ulcers, and underscores the importance of characterizing these biopolymers to enhance their bioactivity for better tissue regeneration outcomes.
July 2026 in “Biomimetics” This review discusses recent advancements in bone tissue engineering, emphasizing a shift from passive to smart responsive antibacterial strategies to prevent implant-associated infections, and highlights AI's role in optimizing bone scaffold design for personalized, infection-free implants.
8 citations
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May 2025 in “Biomimetics” In this review, cellulose-based nanofibers are highlighted for their potential in wound care, given their biodegradability, biocompatibility, and ability to enhance antimicrobial properties and drug delivery in wound dressings through modern fabrication techniques like electrospinning.
1 citations
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July 2023 in “Biomimetics” This study found that a hair-coating polyphenol complex significantly enhanced the mechanical strength, UV protection, and antistatic properties of damaged hair, suggesting potential benefits for hair treatment.
February 2024 in “Skin Research and Technology” This study found that combining scalp repair serum microneedles with oral and topical medications significantly improved hair regrowth in patients with moderate to severe androgenetic alopecia.
January 2024 in “Skin appendage disorders” This article reviews existing research on the treatment of alopecia areata using growth factors and microneedling, reporting that these methods show promise in promoting hair growth without major adverse effects, but emphasizes the need for additional large-scale studies to confirm their efficacy and safety.
2 citations
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July 2021 in “Biochemical and Biophysical Research Communications” This study found that plantar dermis matrix homogenate can partially restore the regenerative capacity of hair follicles impaired in culture, with CTHRC1 playing a critical role in this process.
42 citations
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February 2021 in “Signal Transduction and Targeted Therapy” This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.
13 citations
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January 2016 in “Journal of cosmetology & trichology” This review discusses the emerging pathophysiological factors and potential new therapies for androgenetic alopecia beyond traditional treatments, but reports no new results.
12 citations
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January 2018 in “Biomaterials Science” This study observed that dermal papilla cell aggregates showed increased viability and gene expression on softer 3D substrates, indicating the importance of substrate stiffness in cellular behavior.
January 2026 in “Frontiers in Medicine” In this study, PP-PTKL exhibited antioxidant, anti-inflammatory, and pro-melanogenic effects in laboratory settings, suggesting its potential role in preventing or treating hair greying. Further animal and human studies are needed to verify these findings.
April 2024 in “Nepal journal of dermatology, venereology & leprology” This article discusses the challenges in understanding and treating premature graying of hair and calls for more extensive research, reporting no new findings.
7 citations
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June 2021 in “Cell Proliferation” This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.
36 citations
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August 2011 in “Journal of Controlled Release” This review explores the potential of using genetically-manipulated stem cells as both therapeutic agents and gene delivery vehicles for enhanced wound regeneration, but it reports no new clinical results.
February 2026 in “Frontiers in Medical Technology” This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.
112 citations
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November 2023 in “Nano-Micro Letters” This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
4 citations
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February 2021 in “Nano select” This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.
4 citations
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August 2020 in “Applied Materials Today” This study suggests that human dermal fibroblasts can be converted into dermal papilla cell-like cells using microencapsulation, which may facilitate hair follicle regeneration in mice without chemical or genetic reprogramming.
2 citations
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June 2022 in “Scientific reports” In this study, one type of commercial culture medium supported expression of stem cell markers in hair follicle epithelial stem cells, but their differentiation potential and hair follicle-inducing ability declined over time.
1 citations
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December 2023 in “Scientific reports” This study investigated the use of 3D cell culture technology to explore hair follicle regeneration, examining the impact of the 3D cellular environment on hair follicle morphogenesis and the effects of microwell depth on spheroid formation.
January 2026 in “International Journal of Applied Pharmaceutics” This review discusses the integration of nanoparticles with microneedles to improve drug delivery through enhanced stability, bioavailability, and controlled release, noting ongoing challenges with stability, scalability, and safety.
September 2025 in “Nano Biomedicine and Engineering” This review summarizes recent advances in nanomedicine-based therapies for psoriasis, highlighting their potential to provide targeted and sustained therapeutic effects by modulating key cellular components and signaling pathways involved in the disease, offering novel perspectives for future treatment development.