Cellulose-Based Nanofibers in Wound Dressing

Cellulose-based nanofibers are promising materials for wound dressings due to their biodegradability, biocompatibility, and structural similarity to the extracellular matrix. They can be processed into films, fibers, and membranes with tailored properties, enhancing antimicrobial properties and supporting sustained drug release. Techniques like electrospinning allow precise control over fiber morphology, making them ideal for tissue engineering. Surface functionalization, such as chemical modification and biomolecule immobilization, improves biocompatibility, antimicrobial activity, and mechanical strength. Incorporating nanoparticles, like silver, copper, and zinc oxide, imparts antimicrobial properties, combating drug-resistant microorganisms. Cellulose derivatives, such as cellulose acetate, enhance membrane characteristics for filtration and separation. Bacterial cellulose (BC) is noted for its mechanical properties and potential for drug loading. Future research should focus on advanced functionalization techniques, stimuli-responsive dressings, and clinical trials to enhance performance and clinical application, potentially leading to next-generation therapeutic wound dressings.