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The top research priorities for congenital ichthyosis include long-term side effects of oral retinoids, best topical treatments, and treatments for itch and hair loss.

Blood stem cells are diverse, influenced by many factors, and understanding them is key for progress in regenerative medicine.

New treatments and diagnostic methods for various animal skin conditions showed promising results.

Using anthralin and calcipotriene together might help treat tough cases of alopecia areata, but more research is needed to understand how it works.

Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Bee venom might be a good alternative treatment for various skin conditions because it has many healing properties.

Epidermal keratinocytes start wound healing and inflammation after schistosome infection.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

Loss of keratin K2 causes skin problems and inflammation.

People with alopecia areata often have higher rates of allergies and autoimmune diseases.

Non-invasive methods show promise for diagnosing skin diseases like psoriasis and lupus but need more research for regular use.