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    Glossary ATAC-seq

    technique identifies open chromatin regions to study gene regulation

    ATAC-seq, or Assay for Transposase-Accessible Chromatin using sequencing, is a technique used to study the accessibility of chromatin, which is the material that makes up chromosomes. By identifying regions of DNA that are open and accessible, ATAC-seq helps researchers understand which parts of the genome are active and potentially involved in gene regulation. This method is valuable for studying gene expression patterns in various biological contexts, including development, disease, and cellular responses.

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    Research 30 of 160

    1. 164 Epigenetic and transcriptional profiling of PBMCs in mild and severe alopecia areata using single-cell RNA-Seq and ATAC-Seq Journal of Investigative Dermatology · 2023
    2. 1378 A multi-omics approach to identifying factors involved in hair follicle growth and development Journal of Investigative Dermatology · 2023
    3. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation 2023
    4. Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease bioRxiv (Cold Spring Harbor Laboratory) · 2022
    5. States and Fates of Skin Fibroblasts Revealed through Chromatin Accessibility Journal of Investigative Dermatology · 2022
    6. 708 Promotion of hair growth in alopecia areata by topical treatment of HDAC inhibitors 2019
    7. 1418 Characterization of ectomesenchyme as an origin of epidermal stem cells Journal of Investigative Dermatology · 2023
    8. Single-cell chromatin landscapes of mouse skin development Scientific Data · 2022 · 2 citations
    9. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing Cell stem cell · 2020 · 128 citations
    10. Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging Frontiers in Aging · 2023 · 3 citations
    11. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018 · 85 citations
    12. Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification BMC genomics · 2018 · 7 citations
    13. Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome Advanced Science · 2026
    14. Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma Frontiers in genetics · 2024
    15. Single-Cell Sequencing Technology in Ruminant Livestock: Challenges and Opportunities Current Issues in Molecular Biology · 2024 · 5 citations
    16. Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease Cell Transplantation · 2016 · 1 citations
    17. RNA-seq analysis identifies key genes enhancing hoof strength to withstand barefoot racing in Standardbred trotters BMC Genomics · 2025
    18. Molecular heterogeneity of quiescent melanocyte stem cells revealed by single‐cell RNA‐sequencing Pigment cell & melanoma research · 2024
    19. Stem cell dynamics, migration and plasticity during wound healing Nature Cell Biology · 2018 · 211 citations
    20. CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing International Journal of Molecular Sciences · 2025
    21. scMC learns biological variation through the alignment of multiple single-cell genomics datasets Genome biology · 2021 · 822 citations
    22. Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing Burns & Trauma · 2025 · 5 citations
    23. The molecular anatomy of cashmere goat hair follicle during cytodifferentiation stage BMC Genomics · 2024
    24. Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of <i>Foxn1</i> in Thymic Epithelial Cells 2019 · 17 citations
    25. The Skin Microbiome: Current Landscape and Future Opportunities International Journal of Molecular Sciences · 2023 · 114 citations
    26. Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis Genome biology · 2025
    27. Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses PNAS Nexus · 2025
    28. Skin fibroblast functional heterogeneity in health and disease The Journal of Pathology · 2023 · 1 citations
    29. Advances in single-cell transcriptomics in animal research 2024 · 21 citations
    30. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations