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Flutamide caused damage to male rat reproductive organs and may affect fertility.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Asian hair loss differs from Europeans; consider individual needs and psychological well-being for treatment.

Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Exosomes from stem cells help hair regrowth by activating a specific signaling pathway.

Female pattern hair loss is different from male pattern hair loss and has unclear genetic causes.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Finasteride in male rats causes liver and metabolic issues in their offspring.

New regenerative therapies show promise for treating hair loss.

AR polyglycine repeat doesn't cause baldness.

Gene differences affect finasteride side effects in men with hair loss.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Reduced AR gene methylation may cause early pubic hair growth in girls.

G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.

AR gene not major factor in female hair loss; different from male hair loss.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.