Androgen Receptor Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males with Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

    March 2017 in “ European Urology Supplements ”
    Giovanni Chiriaco, Sabina Cauci, Emanuela Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
    Image of study
    TLDR Gene differences affect finasteride side effects in men with hair loss.
    The study explored whether certain gene polymorphisms in the androgen receptor (AR) gene are implicated in Post-Finasteride Syndrome (PFS), which are long-term adverse symptoms experienced by men who used finasteride as an oral drug against androgenic alopecia (AGA). The study found that the short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms experienced by PFS patients, likely reflecting the vast array of genes modulated by the AR. The study also found a U-curvilinear profile of (CAG)n repeats for skin dryness symptom, where both extremes had a worse condition than medium repeats. Further studies are needed to investigate the PFS pathophysiology using a precision medicine approach.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 3 months 5g Min only before/after, 26 y/o

      in Is this regrowth?  449 upvotes 1 week ago
      The user experienced significant hair regrowth after three months of using 5 mg oral minoxidil nightly and plans to add finasteride to maintain progress. Many recommend combining minoxidil with finasteride or dutasteride to prevent future hair loss.

      community Found this meme on a forum……..

      in Satire  150 upvotes 11 months ago
      The conversation is about a meme related to hair loss that influenced someone to start taking finasteride. Another person agrees that the meme accurately represents the situation.

      community Binding affinity of pyrilutamide!

      in Update  167 upvotes 2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Hair loss causes are still a myth.

      in Chat  16 upvotes 3 years ago
      The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  122 upvotes 1 year ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

    Related Research

    7 / 7 results