Androgen Receptor Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males with Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

    March 2017 in “ European Urology Supplements ”
    Giovanni Chiriaco, Sabina Cauci, Emanuela Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
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    TLDR Gene differences affect finasteride side effects in men with hair loss.
    The study explored whether certain gene polymorphisms in the androgen receptor (AR) gene are implicated in Post-Finasteride Syndrome (PFS), which are long-term adverse symptoms experienced by men who used finasteride as an oral drug against androgenic alopecia (AGA). The study found that the short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms experienced by PFS patients, likely reflecting the vast array of genes modulated by the AR. The study also found a U-curvilinear profile of (CAG)n repeats for skin dryness symptom, where both extremes had a worse condition than medium repeats. Further studies are needed to investigate the PFS pathophysiology using a precision medicine approach.
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