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    Glossary APC Down-Regulated 1

    gene involved in hair growth and development

    APC Down-Regulated 1 (APCDD1) is a gene that plays a role in hair growth and development. Mutations in this gene have been linked to hereditary hypotrichosis simplex, a condition characterized by progressive hair loss starting in childhood. This gene is involved in the Wnt signaling pathway, which is crucial for the regulation of hair follicle development and cycling.

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    1. Hypoxia-Derived Mesenchymal Stem Cell Exosomes Downregulate CXCL12 and Upregulate IL-10 Expression in a Murine Model of Androgenic Alopecia Molecular and Cellular Biomedical Sciences · 2026
    2. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    3. The role of Pygo2 during intestinal tumor initiation and progression in vivo 2016
    4. In Human Skin, UVB Initiates Early Induction of IL-10 Over IL-12 Preferentially in the Expanding Dermal Monocytic/Macrophagic Population Journal of Investigative Dermatology · 1998 · 101 citations
    5. Argan (Argania Spinosa) press cake extract enhances cell proliferation and prevents oxidative stress and inflammation of human dermal papilla cells Journal of dermatological science · 2021 · 14 citations
    6. Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles Clinical, cosmetic and investigational dermatology · 2023 · 1 citations
    7. The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus) BMC Genomics · 2018 · 17 citations
    8. Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior Journal of Ethnopharmacology · 2014 · 19 citations
    9. Anti-proliferative effect of terpenes on human prostate cáncer cells: natural sources and their potential role as chemopreventive agents. Revista chilena de nutrición · 2017 · 3 citations
    10. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012 · 22 citations
    11. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    12. IL-17a induces age-related olfactory dysfunction by impairing regeneration and promoting respiratory metaplasia in mice Nature Communications · 2025
    13. Identification of key genes induced by platelet-rich plasma in human dermal papilla cells using bioinformatics methods Molecular Medicine Reports · 2016 · 16 citations
    14. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020 · 12 citations
    15. An important role of podoplanin in hair follicle growth PLoS ONE · 2019 · 13 citations
    16. Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment Experimental and Therapeutic Medicine · 2019 · 7 citations
    17. Type 2 innate immunity regulates hair follicle homeostasis to control <i>Demodex</i> pathosymbionts bioRxiv (Cold Spring Harbor Laboratory) · 2021
    18. Effects of Biomaterials Derived from Germinated Hemp Seeds on Stressed Hair Stem Cells and Immune Cells International Journal of Molecular Sciences · 2024
    19. Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression Stem Cell Research & Therapy · 2021 · 50 citations
    20. β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid Aging · 2019 · 42 citations
    21. Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be associated with curly hair initiation and maintenance in Mangalitza pigs Frontiers in Genetics · 2023
    22. Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice International Journal of Molecular Medicine · 2018 · 23 citations
    23. Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity Cancer Research · 2006 · 70 citations
    24. MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata 2023
    25. Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways Journal of Nanobiotechnology · 2025 · 9 citations
    26. Quiescent Tissue Stem Cells Evade Immune Surveillance Immunity · 2018 · 169 citations
    27. Antiandrogens as Therapies for COVID-19: A Systematic Review Cancers · 2024 · 6 citations
    28. Targeting lymphoid-derived IL-17 signaling to delay skin aging Nature Aging · 2023 · 59 citations
    29. Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits International journal of molecular sciences · 2024
    30. mRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia International Journal of Molecular Sciences · 2023