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This study reported the first comprehensive transcriptome atlas of the extraorbital lacrimal gland in mice, identifying over 41 cell subclasses and revealing significant cell-cell communication networks, particularly among innate lymphoid cells.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

In this research, LEF1 was identified as a crucial transcription factor for submucosal gland development in mouse and ferret tracheas, though it requires other factors to induce gland formation.

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

This review discusses the medicinal chemistry of steroid sulfatase inhibitors for estrogen- and androgen-dependent disorders but reports no new clinical results.

This study found that KrasG12D mutant cells are typically cleared from adult pancreas tissues through mechanisms involving the EphA2 receptor, suggesting its role as a tumor suppressor in pancreatic cancer.

This study found that recombinant human ADM2 treatment inhibited cell proliferation and induced apoptosis in human hair follicles, contrasting with the previously documented pro-proliferative and anti-apoptotic functions of ADM2.

This article discusses how activating the hexosamine pathway may enhance skin homeostasis by increasing hyaluronic acid secretion and supporting hair follicle stem cell self-renewal, but reports no new results.

This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.

This study found that testosterone significantly influenced the expression and function of certain ion transporters in the vas deferens, impacting fluid secretion and contributing to a suitable environment for male fertility.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

This study discovered a novel mechanism by which germ stem cells exit their niche in C. elegans, involving thin membranous protrusions from adjacent somatic gonad cells.

This study found that exosomes derived from human amniotic mesenchymal stem cells enhanced stem cell proliferation and structural restoration in irradiated salivary glands of rats, with significant improvements observed by day 7, suggesting activation of the Wnt signaling pathway.

This study reports that 2-(1-Adamantyl)-4H-thiochromen-4-on-6-O-sulfamate is the most potent steroid sulfatase inhibitor identified so far, exhibiting 170-fold higher activity than the lead compound estrone sulfamate.

Balanced protease activity is crucial for healthy skin and hair development.

This study demonstrated that the glycolytic inhibitor 2-deoxy-D-glucose enhances antiseizure effects by potentiating extrasynaptic tonic GABAergic inhibition through neurosteroidogenesis in hippocampal slices.

This review discusses the multifunctional role of subcutaneous adipocytes, their contribution to metabolic and pathological processes, and reports no new experimental results; it suggests potential protective roles against metabolic syndrome.

This study observed that mouse preputial glands share general characteristics with rat glands but differ in their intimate association with a hair follicle and absence of proteinaceous granules.

This article explores how the integrated stress response and senescence-associated secretory phenotype influence stem cell fate decisions, highlighting their dual roles in both protecting and disrupting stem cell integrity.

This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.

This study found that SDG did not significantly affect prostate weight in rats with BPH, but it may reduce serum PAP activity and alter prostate tissue changes induced by Testosterone Propionate.

This study demonstrated that in genetic mouse models, the calcium sensor Stim1, not Stim2, is essential for sweat secretion in sweat glands.

This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

This study found that Plant Elicitor Peptides enhance root hair growth through a mechanism independent of their known receptors, with PROPEP2 playing a key role in this process by influencing gene expression related to root hair formation.

This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.

This study found that exosomes from hyaluronic acid-primed mesenchymal stem cells may promote hair growth in androgenetic alopecia by improving hair follicle cell function and restoring key signaling pathways disrupted by DHT.

This study demonstrated that elevated glucocorticoid levels in transgenic mice led to pancreatic exocrine cells transforming into hepatocyte-like cells, resulting in pancreatic dysfunction.

This study found that increased MSI2 expression in hair follicle stem cells can delay hair growth by maintaining stem cell quiescence and repressing Hedgehog signaling.

This editorial reviews the roles and therapeutic potential of inward rectifying K+ channels in various physiological processes, highlighting their importance in health and disease but provides no new experimental results.

This study found that while both natural and bioengineered salivary glands showed similar protein concentrations in response to taste stimulation, their protein compositions and amylase concentrations differed, which may affect nerve signal balance.