Analysis of the Heterogeneity and Complexity of Murine Extraorbital Lacrimal Gland via Single-Cell RNA Sequencing

    May 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Sen Zou, Xinwei Jiao, Shenzhen Huang, Jiangman Liu, Hongli Si, Di Qi, Xiaoting Pei, Dingli Lu, Yimian Wang, Zhijie Li
    Studysummary This study reported the first comprehensive transcriptome atlas of the extraorbital lacrimal gland in mice, identifying over 41 cell subclasses and revealing significant cell-cell communication networks, particularly among innate lymphoid cells. Our plain-language summary of this paper — not a Tressless recommendation.
    This study utilized single-cell RNA sequencing to analyze the cellular diversity and heterogeneity of the extraorbital lacrimal gland (ELG) in C57BL/6J mice, examining 48,077 high-quality cells. The research identified over 41 subclasses of cells, including various types of glandular epithelial cells, fibroblasts, immune cells, vascular-associated cells, and Schwann cells. The study also explored cell-cell communication networks, highlighting the significant role of innate lymphoid cells. This comprehensive transcriptome atlas provides a valuable resource for understanding the biology and pathophysiology of the lacrimal gland and its related diseases.
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