Analysis of the Heterogeneity and Complexity of Murine Extraorbital Lacrimal Gland via Single-Cell RNA Sequencing

This study utilized single-cell RNA sequencing to analyze the cellular diversity and heterogeneity of the extraorbital lacrimal gland (ELG) in C57BL/6J mice, examining 48,077 high-quality cells. The research identified over 41 subclasses of cells, including various types of glandular epithelial cells, fibroblasts, immune cells, vascular-associated cells, and Schwann cells. The study also explored cell-cell communication networks, highlighting the significant role of innate lymphoid cells. The findings provide a comprehensive transcriptome atlas and database for the mouse ELG, which can enhance the understanding of lacrimal gland biology and the pathophysiology of related diseases.