Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-Alpha

May 2011 in “ Journal of Neuroendocrinology ”

Giuseppina Mattace Raso, Emanuela Esposito, S. Vitiello, A Iacono, Anna Santoro, Giuseppe D’Agostino, Oscar Sasso, Roberto Russo, Pier Vincenzo Piazza, Antonio Calignano, Rosaria Meli

palmitoylethanolamide peroxisome-proliferator activated receptor-α neurosteroidogenesis astrocytes steroidogenic acute regulatory protein cytochrome P450 enzyme allopregnanolone oxidative stress finasteride PEA PPAR-α StAR P450scc ALLO

Studysummary This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

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