Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA A Miniature IPSCs in Lamina II of the Spinal Cord

    January 2004 in “ Journal of Neuroscience ”
    Anne Florence Keller, Jean‐Didier Breton, Rémy Schlichter, Pierrick Poisbeau
    Studysummary This study found that inhibiting neurosteroidogenesis affected GABA A receptor-mediated synaptic inhibition in immature rats but not in adults, suggesting age-dependent modulation of synaptic strength in the spinal dorsal horn.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jneurosci.org →
    Discuss this study in the Community →

    Research cited in this study 2

    1. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    2. Neuronal Model of Tactile Allodynia Produced by Spinal Strychnine: Effects of Excitatory Amino Acid Receptor Antagonists and a Mu-Opiate Receptor Agonist Pain · 1996

    Related research 1

    1. Relating Neurosteroid Modulation of Inhibitory Neurotransmission to Behavior Journal of Neuroendocrinology · 2021