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December 2006 in “ Experimental Dermatology ”

Ralf Paus, Charles M. Lapière, Erik Maquoi

adipocytes subcutis hair follicle anagen phase adipokines lipid metabolism subcutaneous fat

TLDR Adipocytes have diverse roles in energy storage, protection, tissue repair, and influence health and disease.

The document discussed the multifaceted roles of adipocytes in the subcutis, highlighting their historical and cultural significance, structural functions, and involvement in various physiological processes. Adipocytes were noted for their energy storage, mechanical protection, and potential as a stem cell repository. They played roles in tissue repair and hair follicle support during the anagen phase. The document also explored adipocytes' secretory functions, producing adipokines that influence lipid metabolism, inflammation, and vascular health. In the context of metabolic syndrome, subcutaneous fat was suggested to act as a protective metabolic sink, challenging previous paradigms. Additionally, adipocytes were implicated in cancer development through their secretory activities, influencing tumor behavior and progression. The document emphasized the complex interactions between adipocytes and other cells, contributing to both health and disease states.

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research Sca-1+ Cells with an Adipocyte Phenotype in Neonatal Mouse Skin

28 citations , July 2005 in “Journal of Investigative Dermatology”

Sca-1+ cells in newborn mouse skin may become fat cells.

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