69 citations
,
May 1997 in “Veterinary Pathology” This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.
36 citations
,
October 1996 in “Dermatologic Clinics” In this study, a methanol extract of Eclipta alba was found to have dose-dependent hair growth-promoting activity in C57BL6 mice.
1 citations
,
May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This paper reviews several dermatological studies, including findings on hair growth, skin damage, bullous pemphigoid, and psoriasis treatments, and reports no new clinical results.
10 citations
,
November 2008 in “Veterinary Dermatology” In this study, the misshaped and hairy ear phenotype in mutant mice was linked to mis-expression of certain Hoxc genes due to a chromosomal inversion.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
2 citations
,
May 2023 in “Veterinary Pathology” This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.
50 citations
,
February 2004 in “Genomics” This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.
2 citations
,
March 2022 in “Research Square (Research Square)” In this study, the expression of certain hair follicle-related genes differed between growth phases in Angora goats, with HOXC13 showing overexpression during the anagen phase, potentially influencing the mohair's shine and texture.
November 2022 in “Research Square (Research Square)” This study found that HOXC13 gene expression was significantly higher during the anagen phase in Angora goats, potentially contributing to the mohair's shiny and silky nature.
75 citations
,
October 2010 in “Mammalian genome” In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.
35 citations
,
May 2019 in “Frontiers in genetics” This study reported that specific non-coding RNAs may regulate the hair follicle cycle in Angora rabbits by acting as competitive endogenous RNAs, enhancing understanding of ncRNA roles in hair growth.
90 citations
,
October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
January 2000 in “BioScience” The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.
759 citations
,
February 2009 in “Current Biology” This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.
3 citations
,
May 2018 in “InTech eBooks” This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.
75 citations
,
September 2007 in “Journal of Heredity” This study found that mutations in the FGF5 gene are the primary genetic factor causing long hair in domestic cats through an autosomal recessive mechanism.
56 citations
,
September 2010 in “Veterinary pathology” This study found that certain C57BL/6 mouse substrains have a genetic vulnerability to skin lesions resembling central centrifugal cicatrical alopecia in humans, potentially worsened by high vitamin A levels.
9 citations
,
April 2006 in “American Journal of Pathology” This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.
6 citations
,
October 2022 in “International Journal of Molecular Sciences” This study found that Fgf5 mutant mice exhibited longer hair, particularly in males, likely due to a prolonged anagen phase in the hair cycle.
December 2024 in “Veterinary Sciences” In this study of Zhexi Angora rabbits, researchers found that the fine-wool group exhibited lower fiber diameters and a higher hair follicle density than the coarse-wool group, and they identified key candidate genes potentially regulating wool quality through RNA-seq and genome resequencing techniques.
March 2024 in “International journal of molecular sciences” In this study on Angora rabbits, researchers identified genetic factors influencing wool fiber diameter by analyzing hair follicle proteins, highlighting keratin family members and other proteins as key contributors to fiber differences between coarse and fine wool.
March 2026 in “World Rabbit Science” This study found that overexpression and knockdown of DKK4 influence genes involved in hair follicle growth and development in Angora rabbits and identified specific SNPs in DKK4 associated with wool quality, notably showing that the TT/GG haplotype combination relates to higher fibre diameters.
January 2021 in “Research Square (Research Square)” This study found that Wan strain Angora rabbits with high wool production exhibited higher hair follicle density and identified long noncoding RNAs that may regulate this trait.
September 2020 in “Research Square (Research Square)” This study found that Wan strain Angora rabbits with high wool production had higher hair follicle density and identified five long noncoding RNAs as potential regulators of this trait.
81 citations
,
September 2009 in “Birth defects research” This review discusses the mechanisms behind hair patterning during mouse embryonic development and reports no new experimental findings.
271 citations
,
March 1999 in “Developmental biology” This study reveals that overexpression of Wnt3 in transgenic mouse skin leads to a short-hair phenotype and cyclical balding due to structural defects in hair shafts, highlighting a role for WNT signaling in hair growth regulation.
26 citations
,
December 2020 in “Genes” This study found that a combination of insulin-like growth factor-1 and epidermal growth factor significantly promoted hair follicle growth and development in both cultured hair follicles and rabbits.
8 citations
,
September 2020 in “Genes & Genomics”
This genetic study identified a potential interval for the Marie Unna hypotrichosis gene but found no mutations in the nearby hr gene, suggesting its involvement remains unconfirmed.
66 citations
,
August 2001 in “Experimental Dermatology” This study demonstrated that intact adult human dermal papillae can induce hair growth when implanted into mouse hair follicles, highlighting their potential for advancing hair follicle biology and therapeutic approaches.