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Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Finasteride is not expected to be effective for treating Acne vulgaris.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

Testosterone's muscle-building effects do not require its conversion to DHT.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.