Identification of Hepatic Molecular Mechanisms of Action of Alpha-Tocopherol Using Global Gene Expression Profile Analysis in Rats

    May 2004 in “ Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ”
    Luca Barella
    TLDR Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.
    The study examined the impact of vitamin E (VE) on liver gene expression in rats over 9 months, revealing that VE influenced genes beyond its antioxidant role. Involving 60 male rats, the research used microarray technology to identify VE-sensitive genes, finding that VE supplementation up-regulated gamma-glutamyl-cysteinyl synthetase, enhancing oxidative stress resistance, and down-regulated genes like scavenger receptor CD36 and coagulation factor IX, suggesting potential anticoagulant effects. Additionally, VE reduced 5-α-steroid reductase type 1 expression, impacting androgen metabolism. These findings indicated VE's significant role in liver metabolic processes, affecting redox homeostasis, coagulation, and androgen-related pathways.
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