Effects of the Anti-Androgen Finasteride on 5-Alpha-Reductase Activity in Human Gingival Fibroblasts in Response to Minocycline
January 1998
in “
Journal of Clinical Periodontology
”
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Studysummary Finasteride helps treat hair loss by blocking enzyme activity.
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The study found that finasteride can inhibit 5-alpha-reductase activity in human gingival fibroblasts, which could be beneficial for treating hair loss and alopecia. The study involved 12 subjects aged 30-50 years. The optimal inhibitory concentration was determined through experiments with multiple cell-lines. The study suggests that finasteride may be useful in treating androgen-related conditions in the gingiva, but further research is needed to confirm these findings and determine the optimal dosage and treatment duration.
