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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Longer CAG and GGN repeats increase alopecia risk, but no significant link to post-finasteride syndrome found.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

The conclusion is that androgen receptor gene polymorphism might be a marker for polycystic ovary syndrome, but more research is needed.

Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.

Finasteride works better for baldness in people with shorter gene repeats.

Finasteride may improve prostate cancer treatment outcomes.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

No clear link between androgen receptor variation and hair loss, but more research needed.

Hair loss gene linked to prostate issues.

The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

No significant link between CAG repeat numbers and female pattern hair loss in Han Chinese population.

Tamoxifen may cause female hair loss by increasing androgen receptor expression.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

No clear link between specific gene and hair loss in Mexican brothers.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Two gene areas linked to male pattern baldness found, more research needed.

A certain gene variant may increase the risk of polycystic ovary syndrome in Chinese women.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Finasteride may cause kidney damage.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.