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The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Finasteride remains stable for two years with proper storage.

New, cheaper method measures finasteride in tablets accurately and quickly.

Method measures finasteride in plasma, suitable for pharmacokinetic studies.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Both drugs lower DHT levels, with GI198745 being more effective.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Certain drugs that block specific enzymes can help treat prostate diseases.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

Method detects finasteride in plasma and semen with high sensitivity and accuracy.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Nanotechnology could make hair loss treatments more effective and reduce side effects, but more research is needed before it's available.

Three new finasteride solvates found, change forms under different drying conditions.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.

Flutamide, dutasteride, and finasteride dissolve differently in supercritical carbon dioxide, with dutasteride dissolving the least.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Finasteride and analogues separated using LC-MS-MS technique.

Finasteride's polymorphic form affects capsule quality and drug effect, requiring strict control.

New tests detect finasteride and dutasteride in urine quickly and easily.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

New method effectively analyzes finasteride and its stability.

Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.

The PW91 method is best for calculating the basic physical and chemical properties of Finasteride, a drug used for prostate issues and hair loss.

Method found to accurately identify finasteride impurities using liquid chromatography.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.