Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review article summarizes the potential role of advanced medical therapies—using genes, cells, and/or tissue engineering—in treating various types of alopecia, by examining clinical research, basic studies, and ongoing trials.

This review discusses the distinction between platelet-rich plasma and stem cell-based therapies in regenerative medicine, highlighting their different roles and stressing the importance of honest representation by commercial and health entities.

This study developed a method for generating germ-like tissues called bbHFGs, which efficiently promoted hair follicle formation in mice, potentially advancing hair regenerative medicine applications.

This study observed that NSPC predominantly differentiated into neurons when exposed to serum fractions with molecules under 100 kDa, particularly with biomaterial and fibronectin, in the presence of basic fibroblast growth factor.

This study found that human hair follicle dermal cells, specifically dermal sheath cells, can serve as an alternative and potentially superior cell source for constructing the dermal component of bioengineered skin in both in vitro and in vivo settings.

This review covers cell transplantation methods for genitourinary reconstruction, discussing tissue sources and complications but presenting no new clinical findings.

In this study, researchers demonstrated that the Id2 gene acts as a direct target and effector of BMP signaling, playing a key role in maintaining quiescence in hair follicle stem cells in vivo.

In this study, bovine milk-derived oligosaccharides were found to increase sebocyte proliferation, lipid content, and inflammatory mediator synthesis through the mTORC1 pathway, potentially contributing to milk-based inflammation in sebocytes.

This study found that a single dose of TRP significantly reduced the number of UV-B-induced actinic keratosis lesions in a mouse model and was associated with improved skin histology and minimal side effects.

This case study reports that a heterozygous missense GJA1 mutation, p.Gly138Ser, in a 2-year-old boy with oculodentodigital syndrome primarily resulted in syndactyly, fifth finger hypoplasia, and hypotrichosis, without neurological or craniofacial abnormalities.

This study found that anagen hair follicles can quickly regenerate after radiation damage by forming new progenitor cells outside the bulge, bypassing the need for telogen entry.

This review discusses the current challenges and strategies in hair follicle bioengineering for treating hair loss and reports no new clinical results; it highlights ongoing hurdles and future directions for developing functional hair regeneration therapies.

This study reported that a novel chitosan/polyvinyl alcohol nanofiber sponge effectively enhances the hair follicle-inducing ability of dermal papilla multicellular spheroids in a mouse model.

This study found that SA-MS hydrogel released Mo4+ ions which promoted healing of disease-impaired wounds by enhancing cell proliferation and angiogenesis, and through its photothermal effects addressed skin cancer-impaired wounds in mice.

This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.

This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.

This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.

In this review, researchers examined how needle gauge and length impact the viability of human stem cells during injections, emphasizing the balance between minimizing tissue trauma and preserving cell viability to optimize clinical protocols.

This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.

This study found that intact pilosebaceous units were more effective than truncated hair follicles at regenerating a multilayered epidermis in a de-epidermalized dermis in vitro.

This review examines microneedle patches for drug delivery, detailing their designs, materials, manufacturing methods, and potential advantages, but reports no new clinical results.

This study suggests that epithelial-derived pop-up keratinocytes (ePUKs) may improve regenerative medicine applications due to their specific phenotype and increased expression of proteins involved in regulating cellular movement and wound healing.

This study suggests that hair follicle dermal stem/progenitor cells play a key role in both hair regeneration and skin wound healing, with potential implications for preventing hair follicle miniaturization linked to aging or alopecia.

This study demonstrated that engineered skin substitutes using human keratinocytes and murine dermal papilla cells can develop pigmented hairs without sebaceous glands, suggesting separate pathways for hair development and eruption.

This study found that using a microwell array device to expand hair follicle stem cells in Matrigel significantly increased cell numbers and enhanced hair regeneration in mice.

This review reports on the principles, applications, and future potential of bioprinting technology in fields like tissue engineering and organ regeneration, highlighting recent advancements and identifying ongoing challenges and future directions that require collaborative efforts to fully realize the technology's capabilities.

This study found that a new "bead-jet" printing system for mesenchymal stem cells in Matrigel beads improved skeletal muscle regeneration and skin healing in a high-density, sparse pattern.

This review discusses dermal cell heterogeneity in wound healing and scar formation, highlighting the varied roles of different fibroblasts and the potential of skin substitutes without presenting new clinical results.