Three-Dimensional Reconstructions of Mechanosensory End Organs Suggest a Unifying Mechanism Underlying Dynamic, Light Touch

March 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Annie Handler, Qiyu Zhang, Song Pang, Tri Nguyen, Michael Iskols, Michael Nolan-Tamariz, Stuart Cattel, Rebecca Plumb, Brianna Sanchez, Karyl Ashjian, Aria Shotland, Bartianna Brown, Madiha Kabeer, Josef Turecek, Genelle Rankin, Wangchu Xiang, Elisa C. Pavarino, Nusrat Africawala, Celine Santiago, Wei-Chung Allen Lee, Chuanyun Xu, David D. Ginty

Meissner corpuscles hair follicles Pacinian corpuscles FIB-SEM electron microscopy axon protrusions Aß RA-LTMR lanceolate endings neurofilaments caveolae Piezo2 channels mechanotransduction sensory axons mechanosensory end organs light touch imaging techniques genetic data electrophysiological data

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

660 citations , December 2011 in “Cell”

This study found that distinct low-threshold mechanoreceptors innervate different hair follicle types in mice, suggesting that these follicles serve as unique mechanosensory structures in touch perception.