Staining of Human Skin With RGB Trichrome Unveils a Proteoglycan-Enriched Zone in the Hair Dermal Sheath

    September 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Clara Serrano-Garrido, Francisco Gaytán

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study applied a new RGB trichrome stain to human skin samples, revealing distinct structural staining in normal tissues and potential proteoglycan-rich zones in hair follicles.
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    Research cited in this study 19

    1. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    2. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    3. Hair Histology and Glycosaminoglycans Distribution Probed by Infrared Spectral Imaging: Focus on Heparan Sulfate Proteoglycan and Glypican-1 During Hair Growth Cycle Biomolecules · 2021
    4. The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis BioEssays · 2020
    5. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    6. The Pathobiology of Skin Aging American Journal Of Pathology · 2020
    7. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    8. Eccrine Sweat Glands Associate With the Human Hair Follicle Within a Defined Compartment of Dermal White Adipose Tissue British Journal of Dermatology · 2018
    9. Identification of Bulge Stem Cells in Mouse and Human Hair Follicles Microscopy research · 2018
    10. The Hair Follicle Enigma Experimental Dermatology · 2017
    11. Distinct Expression Profile of Stem Cell Markers, LGR5 and LGR6, in Basaloid Skin Tumors Virchows Archiv · 2017
    12. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    13. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    14. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012
    15. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    16. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    17. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    18. K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2003
    19. Hair Follicle Proteoglycans Journal of Investigative Dermatology · 1993