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    Intraoperative Bioprinting of Human Adipose-Derived Stem Cells and Extracellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation During Full-Thickness Craniomaxillofacial Skin Reconstruction

    October 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Youngnam Kang, Miji Yeo, Irem Deniz Derman … İbrahim T. Özbolat

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study demonstrated that intraoperative bioprinting using a bioink with human adipose-derived extracellular matrix and stem cells achieved successful reconstruction of full-thickness craniomaxillofacial skin defects in rats, promoting wound closure, adipogenesis, and hair follicle-like structure formation within two weeks.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    2. The Role of Immature and Mature Adipocytes in Hair Cycling Trends in Endocrinology and Metabolism · 2018
    3. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    4. Emerging Nonmetabolic Functions of Skin Fat Nature Reviews Endocrinology · 2018
    5. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    6. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    7. Adipocytes in Skin Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014
    8. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    9. Bioengineering Skin Using Mechanisms of Regeneration and Repair Biomaterials · 2007
    10. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    11. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    12. Local Injection of Hepatocyte Growth Factor/Scatter Factor Alters Cyclic Growth of Murine Hair Follicles Journal of Investigative Dermatology · 1998