Isolation And Identification Of Endophytic Actinobacteria From Citrullus Colocynthis And Their Antibacterial Properties

The study isolated and identified six strains of endophytic actinobacteria (EA) from the Citrullus colocynthis plant, marking the first time these EAs have been reported from this plant. These EAs were classified into two families: Streptomycetaceae and Nocardiopsaceae. Three of these strains were reported as endophytes for the first time. The antibacterial activity of these strains was tested against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, with five strains showing antagonist activity. The study concluded that Citrullus colocynthis could be a potential source for the isolation of EA, which could lead to the discovery of new antibiotics, offering a promising avenue for combating multi-drug resistance diseases.