Cytotoxic And Antioxidant Effect Of The Ethanolic Extract Of Citrullus Colocynthis L. Plant Fruit
May 2021
in “
Genetics and Biodiversity Journal
”
Studysummary In this study, the ethanolic extract of Citrullus colocynthis demonstrated strong antioxidant activity and reduced cancer cell numbers in vitro, suggesting potential for pharmacological use. Our plain-language summary of this paper — not a Tressless recommendation.
The study evaluated the antioxidant and cytotoxic effects of the ethanolic extract of Citrullus colocynthis fruits. The extract was found to be rich in polyphenols, with a content of 443.62 ± 2.13 µg EAG/mg. It demonstrated strong anti-free radical activity against DPPH (CI50 = 6.31 µg/ml) and ferric reducing antioxidant power (CI50 = 27.94 µg/ml), as well as good activity against the OH radical (IC50 = 67.13 µg/ml). The extract also reduced the number of cells in three cancer cell lines (HepG2, SH-SY5Y, and Raw 264.7) in a dose-dependent manner. These findings suggested that Citrullus colocynthis had significant pharmacological potential for use in phytotherapy.
