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This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.

This study identified LY191704 as a specific noncompetitive inhibitor of human 5 alpha-reductase type 1, which may be useful in treating endocrine disorders related to DHT overproduction.

This study demonstrated the expression of type 1 interferon-related proteins in inflammatory lesions of alopecia areata, showing a distinct distribution pattern compared to cicatricial alopecia.

This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.

This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.

In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.

This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.

This study demonstrated that tight junction barriers exist in human hair follicles but are less tight in hair follicle keratinocytes than in interfollicular keratinocytes, highlighting claudin-1's key role in follicle barrier function and growth.

This study reports that GLP-1 receptors and proglucagon are expressed in the skin of newborn mice, with GLP-1 potentially playing a role in skin development and hair follicle formation.

This study found that mechanical stress activates a WISP-1/Hedgehog signaling axis that contributes to ligamentum flavum hypertrophy and fibrosis, identifying Hedgehog signaling as a potential therapeutic target.

This study found that SIRT1 negatively regulates fibroblast activation and excessive scar formation, suggesting it may be a promising drug target for treating hypertrophic scars.

In this study, researchers found that overexpression of IGF-1 in transgenic mice stimulated increased vibrissa growth during the first neonatal hair cycle compared to their nontransgenic littermates.

This study found that in rodent diabetes models, measuring corticosterone levels in new growth hair was more sensitive to hyperglycemia-induced changes than using old hair or serum samples.

This study in Italy found that APS-1, a rare disorder, is associated with various AIRE gene mutations and most individuals have autoantibodies such as IFNωAbs, which are markers of the condition.

This study demonstrated immunological cross-reactivity between mycobacterial heat-shock protein 65 and human epidermal cytokeratin 1/2, suggesting that this cross-reactive epitope might play a role in skin diseases.

In this study, variation in the KRTAP15-1 gene in goats was linked to changes in cashmere fibre diameter, with specific variants showing dominant or recessive effects.

This study found that IGF-1 likely plays a crucial role in regulating hair growth and alopecia, with balding scalp follicles secreting less IGF-1 than nonbalding counterparts.

In this study, researchers identified a novel congenital skin disorder in Chesapeake Bay retrievers, linked to a plakophilin-1 deficiency due to a genetic mutation, marking the first known occurrence in an animal species.

This study found that finasteride treatment reduced caspase-1 expression, suggesting that androgens may influence immune processes in the hair cycle of androgenetic alopecia.

In this study, the combination of SCF and ET-1 was found to significantly enhance skin pigmentation and melanin content in human skin xenografts on SCID mice compared to either treatment alone.

This study found that protease nexin-1 mRNA is expressed in human dermal papilla cells and is downregulated by dihydrotestosterone in balding scalp, suggesting a role in male-pattern baldness progression.

This study found that tannic acid accelerated wound healing in rats by modulating inflammatory cytokines, increasing growth factors, and activating the Erk 1/2 pathway.

This study identified a novel gene, hacl-1, that is specifically expressed in the hair follicles of ICR mouse skin and is associated with their active state.

This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.

This study found that GI198745 acts as a time-dependent inhibitor of rat 5α-reductase type 2 but a rapid-equilibrium inhibitor of type 1, potentially making it more effective than finasteride in preventing rat prostate growth.

In this study, ustekinumab did not promote hair regrowth in human patients with alopecia areata or prevent disease development in an AA mouse model, suggesting limited efficacy for this treatment.

IL-1 receptor absence in mice leads to skin cysts and changes in immune response after UVB exposure.

This study found that lipin 1β expression in both visceral and subcutaneous adipose tissue is significantly lower in PCOS patients compared to controls, suggesting its involvement in the pathogenesis of insulin resistance.