A Randomized, Investigator-Blinded, Controlled, Split-Scalp Study of the Efficacy and Safety of a 1550-nm Fractional Erbium-Glass Laser, Used in Combination with Topical 5% Minoxidil Versus 5% Minoxidil Alone, for the Treatment of Androgenetic Alopecia

    April 2019 in “ Lasers in Medical Science ”
    Poonkiat Suchonwanit, Salinee Rojhirunsakool, Saranya Khunkhet
    Studysummary This study found that combining fractional erbium-glass laser therapy with topical minoxidil significantly improved hair density and diameter in men with androgenetic alopecia compared to using minoxidil alone over a 24-week period, with no serious adverse events reported.
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    Research cited in this study 22

    1. Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia Dermatologic Surgery · 2018
    2. Fractional Non-Ablative Laser-Assisted Drug Delivery Leads to Improvement in Male and Female Pattern Hair Loss Journal of Cosmetic and Laser Therapy · 2018
    3. Therapeutic Efficacy and Safety of a 1927-nm Fractionated Thulium Laser on Pattern Hair Loss: An Evaluator-Blinded, Split-Scalp Study Lasers in Medical Science · 2018
    4. Efficacy of Fractional Lasers in Treating Alopecia: A Literature Review Lasers in Medical Science · 2017
    5. Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors Lasers in Medical Science · 2017
    6. Hair Regrowth Through Wound Healing Process After Ablative Fractional Laser Treatment in a Murine Model Lasers in Surgery and Medicine · 2015
    7. Erbium: YAG Laser (2,940 nm) Treatment Stimulates Hair Growth Through Upregulating Wnt 10b and β-Catenin Expression in C57BL/6 Mice PubMed · 2015
    8. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    9. Transepidermal Drug Delivery: A New Treatment Option for Areata Alopecia? Journal of cosmetic and laser therapy · 2014
    10. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    11. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    12. Clinical Effects of Non-Ablative and Ablative Fractional Lasers on Various Hair Disorders: A Case Series of 17 Patients Journal of Cosmetic and Laser Therapy · 2013
    13. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    14. The Effect of a 1550 Nm Fractional Erbium-Glass Laser in Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2011
    15. Fractional Photothermolysis Laser Treatment of Male Pattern Hair Loss Dermatologic Surgery · 2010
    16. Effect of Helium-Neon Laser Irradiation on Hair Follicle Growth Cycle of Swiss Albino Mice Skin pharmacology and physiology · 2009
    17. HairMax LaserComb Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia Clinical Drug Investigation · 2009
    18. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    19. The Current Role of Laser and Light Sources in the Treatment of Male and Female Pattern Hair Loss Journal of Cosmetic and Laser Therapy · 2007
    20. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    21. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    22. Hair Growth Cycle Affects Hair Follicle Destruction by Ruby Laser Pulses Journal of Investigative Dermatology · 1998

    Related research 9

    1. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris Journal of The American Academy of Dermatology · 2020
    4. A Randomized, Investigator-Blinded, Controlled, Split-Scalp Study of the Efficacy and Safety of a 1550-nm Fractional Erbium-Glass Laser, Used in Combination with Topical 5% Minoxidil Versus 5% Minoxidil Alone, for the Treatment of Androgenetic Alopecia Lasers in Medical Science · 2019
    5. Pustular Dermatosis of the Scalp Due to Topical Minoxidil 5% 2018
    6. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    7. Comparison of the Therapeutic Effect of 2% Topical Minoxidil with Rosemary Solution in the Treatment of Alopecia Areata on the Scalp DOAJ (DOAJ: Directory of Open Access Journals) · 2014
    8. Current Treatment of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013
    9. Erosive Pustular Dermatosis of the Scalp from Topical Minoxidil 5% Solution International Journal of Dermatology · 2011