Serotonin Activates Dermal Papilla Cells and Promotes Hair Growth

    July 2025 in “ Scientific Reports
    Tatsuto Kageyama, Jieun Seo, Lei Yan, Sayuri Hamano, Junji Fukuda
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    TLDR Serotonin helps hair grow by activating certain cells.
    The study demonstrates that serotonin (5-HT) stimulates dermal papilla (DP) cells, promoting hair growth by activating serotonin signaling pathways. Experiments using human DP cells, hair follicloids, and human hair follicle organ cultures showed that 5-HT treatment increased the expression of hair growth-related genes and promoted hair shaft elongation. Additionally, the study explored the potential of sumatriptan succinate, an HTR agonist, to enhance hair growth, suggesting that drug repositioning of existing HTR agonists could lead to new hair growth-promoting treatments. The findings highlight the role of serotonin in hair follicle homeostasis and suggest further research into its mechanisms and potential side effects for alopecia treatment.
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