DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Dorsal Skin Model

    May 2024 in “ Genes ”
    Junko Shibato, Fumiko Takenoya, Ai Kimura … Seiji Shioda
    Studysummary In this study, 20% whale oil applied to mice was observed to promote hair growth more effectively than a control or 3% minoxidil, showing increased hair follicles and thicker subcutaneous tissue.
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    Research cited in this study 24

    1. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview Biomolecules · 2023
    2. Deimination In Epidermal Barrier And Hair Formation Philosophical transactions - Royal Society. Biological sciences · 2023
    3. BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway International Journal of Molecular Sciences · 2023
    4. Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss JAMA dermatology · 2022
    5. Safflower Oil Body Nanoparticles Deliver hFGF10 to Hair Follicles and Reduce Microinflammation to Accelerate Hair Regeneration in Androgenetic Alopecia International Journal of Pharmaceutics · 2022
    6. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    7. Nanoscale Microenvironment Engineering for Expanding Human Hair Follicle Stem Cells and Revealing Their Plasticity Journal of Nanobiotechnology · 2021
    8. Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer Cells · 2020
    9. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    10. An Open-Label Evaluator Blinded Study of the Efficacy and Safety of a New Nutritional Supplement in Androgenetic Alopecia: A Pilot Study PubMed · 2017
    11. Role of Arachidonic Acid in Promoting Hair Growth Annals of dermatology/Annals of Dermatology · 2016
    12. Guidelines on the Use of Finasteride in Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2016
    13. Blockade of S100A3 Activity Inhibits Murine Hair Growth Genetics and Molecular Research · 2015
    14. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    15. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    16. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    17. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    18. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    19. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    20. Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for Their Modes of Action in Hair Follicles Journal of Investigative Dermatology · 2005
    21. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    22. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    23. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    24. Mechanism of Action of Minoxidil Sulfate-Induced Vasodilation: A Role for Increased Potassium Permeability PubMed · 1988

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    3. Treatment of Hair Loss The New England Journal of Medicine · 1999