TMT-Based Quantitative Proteomics Reveals the Genetic Mechanisms of Secondary Hair Follicle Development in Fine-Wool Sheep
February 2025
in “
PLoS ONE
”
secondary hair follicles fine-wool sheep TMT-based quantitative proteomics fetal development skin tissue protein profiles differentially expressed proteins focal adhesion ECM-receptor interaction estrogen signaling pathways COL1A1 THBS3 ITGA6 COL6A1 THBS4 hair follicles wool quality proteomics protein profiles estrogen pathways
TLDR Key proteins influence wool quality by affecting hair follicle development in sheep.
This study explores the genetic mechanisms behind secondary hair follicle development in fine-wool sheep using TMT-based quantitative proteomics. By examining skin tissues at four fetal development stages, researchers identified 509 differentially expressed proteins, with significant increases in secondary hair follicle density observed from 85 to 105 gestational days. Key proteins such as COL1A1, THBS3, ITGA6, COL6A1, and THBS4 were identified as potential initiators of secondary hair follicles. The study highlights the importance of pathways like ECM-receptor interactions, focal adhesion, and estrogen signaling in hair follicle development. These findings enhance the understanding of molecular mechanisms affecting wool quality traits and could inform breeding strategies for improved wool production.
