TMT-Based Quantitative Proteomics Reveals the Genetic Mechanisms of Secondary Hair Follicle Development in Fine-Wool Sheep

February 2025 in “ PLoS ONE ”

Lixia Qiu, Qian Yu, Hua-Qian Zhou, Wenhua Fan, Jingjing Zheng, Yonglin Yang, Wenzhe Zhang, Xin Cao, Hua Yang

secondary hair follicles fine-wool sheep TMT-based quantitative proteomics fetal development skin tissue protein profiles differentially expressed proteins focal adhesion ECM-receptor interaction estrogen signaling pathways COL1A1 THBS3 ITGA6 COL6A1 THBS4 hair follicles wool quality proteomics protein profiles estrogen pathways

Studysummary This study used TMT-based quantitative proteomics to analyze the development of secondary hair follicles in fetal sheep, revealing increased follicle density and key proteins involved, such as COL1A1 and THBS4, indicating their potential role in wool quality traits.

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