Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering

    Shan Chang Chueh, Shen-Chieh Lin, Chih Chiang Chen, Mingxing Lei, Ling Mei Wang, Randall B. Widelitz, Michael W. Hughes, Ting Jiang, Cheng Ming Chuong
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    TLDR The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.
    The 2013 paper discussed four key strategies for hair regeneration: intra-follicle regeneration, extra-follicular factors, wound-induced follicle neogenesis, and tissue engineering. The study highlighted the role of local macro-environmental factors, such as Bone Morphogenetic Proteins (BMPs), and hormones in regulating hair follicle cycles. It also discussed the effects of sex hormones on hair regeneration diseases like androgenic alopecia. The paper further explored the potential of stem cell engineering in hair regeneration, with studies showing that hair follicle neogenesis can be induced in the wound bed of large wounds. It also discussed the potential of tissue engineering of hair follicles and the role of extracellular matrix proteins in enhancing dermal papilla cell aggregation. However, the information might be outdated as the document is 10 years old.
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