Potential Treatment of Steroid-Resistant Alopecia Areata Using Allogeneic Exosomes Derived From Adipose Tissue Mesenchymal Stromal Cells: A Case Report

    July 2026 in “ Clinical Case Reports ”
    Masoumeh Kianpisheh, Mohsen Piroozhashemi, Shabnam Feshangchian-Atashbar … Alireza Shoae‐Hassani
    Studysummary This single-patient case study reported promising results for severe, corticosteroid-resistant alopecia areata, with treatment using exosomes derived from mesenchymal stromal cells leading to almost complete hair regrowth in 12 weeks and favorable changes in inflammatory markers, suggesting potential for further investigation.
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    Research cited in this study 15

    1. Exosome-Based Therapies for Alopecia Areata: A Systematic Review of Clinical and Experimental Evidence International Journal of Molecular Sciences · 2025
    2. Advances in the Extracellular Vesicles Treatment of Alopecia Annals of Medicine · 2025
    3. Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia World Journal of Stem Cells · 2025
    4. Adipose Tissue-Derived Exosomes as a Novel Therapeutic Approach for Refractory Alopecia Areata: A Report of Two Cases Case Reports in Dermatological Medicine · 2025
    5. Is Autologous Platelet-Rich Plasma Capable of Increasing Hair Density in Patients with Androgenic Alopecia? A Systematic Review and Meta-Analysis of Randomized Clinical Trials Anais Brasileiros de Dermatologia · 2024
    6. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    7. Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis Frontiers in pharmacology · 2024
    8. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    9. Bioinspired Engineering of ADSC Nanovesicles in Thermosensitive Hydrogel to Enhance Autophagy of Dermal Papilla Cells for Androgenetic Alopecia Treatment Bioactive Materials · 2024
    10. Autologous Stem Cell-Derived Therapies for Androgenetic Alopecia: A Systematic Review of Randomized Control Trials on Efficacy, Safety, and Outcomes Plastic and Reconstructive Surgery – Global Open · 2024
    11. Autologous Adipose Tissue Injection in the Treatment of Alopecia: A Mini-Review Journal of Cosmetic Dermatology · 2023
    12. Novel Versus Modified Platelet-Rich Plasma Therapy for Hair Loss Treatment: A Systematic Review and Meta-Analysis 2023
    13. Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarriers Controls Chemotherapy-Induced Alopecia Areata International Journal of Molecular Sciences · 2023
    14. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    15. Ideal JAK Inhibitor for Alopecia Areata: Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib - Revisiting the Immunomechanisms of the JAK Pathway Indian Dermatology Online Journal · 2023