Adipose Tissue-Derived Exosomes as a Novel Therapeutic Approach for Refractory Alopecia Areata: A Report of Two Cases

January 2025 in “ Case Reports in Dermatological Medicine ”

Mohammad Ali Nilforoushzadeh, Nazila Heidari, Amirhossein Heidari, Niloufar Najar Nobari

adipose tissue-derived exosomes ASC-exosomes alopecia areata hair follicle regeneration immune response modulation

TLDR Adipose tissue-derived exosomes may help regrow hair in alopecia areata.

This study explores the use of adipose tissue-derived exosomes (ASC-exosomes) as a treatment for refractory alopecia areata in two female patients, both of whom experienced significant hair regrowth and symptom reduction three months post-treatment. The findings suggest ASC-exosomes may aid in hair follicle regeneration and immune response modulation, though the mechanisms are not fully understood. Despite the promising outcomes, the study's small sample size and absence of a control group highlight the necessity for further research with larger cohorts to confirm the efficacy of ASC-exosomes in treating alopecia areata.

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Research cited in this study

14 / 14 results

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research Current Advances in Stem Cell-Based Therapies for Hair Regeneration

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Stem cell therapies show promise for hair regrowth but face production and application challenges.

research Treatment of Alopecia Areata: An Australian Expert Consensus Statement

95 citations , November 2018 in “Australasian journal of dermatology”

Alopecia areata treatment varies, with no optimal method established yet.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

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research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

19 citations , January 2017 in “Stem Cells International”

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A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

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Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

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Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

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