SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice
July 2020
in “EMBO journal”
TLDR SIRT7 protein is crucial for starting hair growth in mice.
The study demonstrated that SIRT7, a protein deacetylase, is essential for the activation of hair follicle stem cells (HFSCs) and the initiation of hair growth in mice. Depletion of SIRT7 resulted in a delayed transition from the telogen to anagen phase, leading to slower hair growth, while overexpression of SIRT7 accelerated this transition and hair growth. The mechanism involves SIRT7-mediated deacetylation and degradation of Nfatc1, a transcriptional regulator that maintains HFSC quiescence. Additionally, SIRT7 levels were found to decrease in aged HFSCs, but its overexpression could promote hair growth in older animals. The study, which typically used around 6 mice per genotype and conducted cell counts on 10 hair germs or bulges per mouse, suggests that SIRT7 is a key regulator of HFSC activation and hair cycle progression, with implications for age-related hair loss treatments.
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