Randomized Controlled Trial on the Efficacy and Safety of the Combination Therapy of Topical 0.1% Finasteride and 5% Minoxidil in Male Androgenetic Alopecia

    April 2025 in “ Archives of Dermatological Research ”
    Farah Faulin Lubis, Lili Legiawati, Martha Saulina, Siti Rizny F Saldi
    Studysummary The combination of finasteride and minoxidil is as safe and effective as minoxidil alone for improving hair growth in men.
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    Research cited in this study 30

    1. Efficacy of Topical Minoxidil and Finasteride Association Compared to Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor-Blinded, 3-Arm, Pilot Trial Journal of Cosmetic Dermatology · 2023
    2. Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia Dermatology and therapy · 2023
    3. Hair Disorder in Dr. Cipto Mangunkusumo Cosmetic Dermatology and Venereology Outpatient Clinic of Jakarta, Indonesia: A Socio-Demographic and Clinical Evaluation Dermatology Reports · 2022
    4. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    5. Comparative Study of Efficacy of Topical Minoxidil Versus Topical Minoxidil With Finasteride in Androgenetic Alopecia International Journal of Research in Dermatology · 2021
    6. Androgenetic Alopecia: Update on Etiology Dermatological reviews · 2021
    7. Management of Androgenetic Alopecia: A Review International Journal of Research in Dermatology · 2021
    8. Trichoscopic Findings in Androgenetic Alopecia Medicinski arhiv · 2021
    9. Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Journal of Dermatological Treatment · 2020
    10. Asian Hair: A Review of Structures, Properties, and Distinctive Disorders Clinical, Cosmetic and Investigational Dermatology · 2020
    11. The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Aesthetic Plastic Surgery · 2020
    12. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    13. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    14. Clinical Profile of Androgenic Alopecia and Its Association with Cardiovascular Risk Factors Indian Journal of Dermatology · 2019
    15. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    16. Comparing the Therapeutic Efficacy of Topical Minoxidil and Finasteride with Topical Minoxidil and Oral Finasteride in Androgenetic Alopecia: A Randomized Trial International Journal of Research in Dermatology · 2018
    17. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    18. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women PubMed · 2018
    19. A Cross-Sectional Randomized Comparative Study of Topical Minoxidil Solution With and Without Finasteride in Male Pattern Androgenetic Alopecia in South Indian Patients International Journal of Research in Dermatology · 2018
    20. Androgenetic Alopecia: A Review Endocrine · 2017
    21. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    22. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    23. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    24. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    25. A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers International Journal of Clinical Pharmacology and Therapeutics · 2014
    26. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    27. Efficacy and Safety of 3% Minoxidil Versus Combined 3% Minoxidil / 0.1% Finasteride in Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Study PubMed · 2012
    28. Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss American Journal of Clinical Dermatology · 2007
    29. Histological Features of Peripilar Signs Associated with Androgenetic Alopecia Archives of Dermatological Research · 2004
    30. Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men Journal of Dermatology · 2002

    Related research 9

    1. Oral Finasteride (5 mg and 2 mg) Versus Topical Minoxidil 5% in Female Pattern Hair Loss Clinical Dermatology Review · 2025
    2. Comparative Study of Topical Minoxidil (5%) Plus Finasteride (0.1%) Versus Platelet-Rich Plasma Plus Topical Minoxidil (5%) Plus Finasteride (0.1%) in Patients with Androgenic Alopecia Asian Journal of Pharmaceutical and Clinical Research · 2024
    3. Faculty Opinions Recommendation of Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    4. Pharmacological Therapeutics in Androgenetic Alopecia Journal of The Korean Medical Association · 2020
    5. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    6. A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia Journal of clinical & experimental dermatology research · 2015
    7. Finasteride in the Treatment of Female Androgenic Alopecia PharmaTutor · 2014
    8. Daily Finasteride Boosts Hair Growth in Men Dermatology Times E-News · 2012
    9. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001