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    Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

    July 2016 in “ The Journal of Sexual Medicine ”
    Luhao Liu, Shankun Zhao, Futian Li … Zhigang Zhao
    Studysummary This study concluded that 5α-reductase inhibitors were linked to increased sexual dysfunction in men with benign prostatic hyperplasia, but not in men with androgenetic alopecia.
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    Research cited in this study 27

    1. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    2. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    3. 5α-Reductase Inhibitors Increase Acute Coronary Syndrome Risk in Patients with Benign Prostate Hyperplasia Journal of Endocrinological Investigation · 2015
    4. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014
    5. Androgen Levels and Semen Parameters Among Former Users of Finasteride With Persistent Sexual Adverse Effects JAMA Dermatology · 2014
    6. A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia Clinical endocrinology · 2014
    7. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    8. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    9. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    10. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
    11. Guidelines for the Management of Androgenetic Alopecia (2010) Journal of Dermatology · 2011
    12. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    13. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    14. Androgenetic Alopecia: Clinical Features, Classification, and Treatments Endocrinology and Metabolism Clinics of North America · 2007
    15. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    16. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    17. Evaluation of Sexual Function With an International Index of Erectile Function in Subjects Taking Finasteride for Androgenetic Alopecia Archives of Dermatology · 2004
    18. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    19. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003
    20. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    21. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    22. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    23. A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride Clinical Pharmacology & Therapeutics · 1998
    24. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    25. The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1998
    26. Finasteride The New England Journal of Medicine · 1994
    27. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992

    Related research 4

    1. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors Sexual medicine reviews · 2018
    2. AB40. Sexual Side Effects of Medical Treatment of BPH PubMed Central · 2014
    3. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    4. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007