5α-Reductase Inhibitors Increase Acute Coronary Syndrome Risk in Patients with Benign Prostate Hyperplasia

    March 2015 in “ Journal of Endocrinological Investigation ”
    Chi-Hung Chou, Cheng-Li Lin, Ming-Chia Lin, Fung-Chang Sung, Chia-Hung Kao
    Image of study
    TLDR Taking both finasteride and dutasteride for prostate issues may raise the risk of heart problems.
    The study analyzed data from the Taiwan National Health Insurance system and found that patients with benign prostate hyperplasia (BPH) who were treated with both finasteride and dutasteride had a 3.47 times higher risk of developing acute coronary syndrome (ACS) compared to those not treated with 5α-reductase inhibitors (5ARIs). The study included 1,843 ACS cases and 7,330 controls, all with a mean age of 73 years. No significant increase in ACS risk was observed in patients treated with only one of the medications. The findings suggest a potential risk associated with the combined use of finasteride and dutasteride, but the study acknowledges limitations such as missing data on lifestyle factors and the possibility of bias from unmeasured variables. Further research with larger sample sizes and more comprehensive data is recommended to confirm these results.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 90 results

      community Massive study on finasteride side effects released

      in Finasteride/Dutasteride  83 upvotes 1 year ago
      The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 11 months ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 9 months ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

    Similar Research

    5 / 1000+ results