5α-Reductase Inhibitors

    September 2014
    Claudius Füllhase, Roberto Soler
    TLDR 5-Alpha reductase inhibitors help treat enlarged prostate but may cause sexual side effects.
    5-Alpha reductase inhibitors (5ARIs), including finasteride and dutasteride, were established treatments for benign prostate hyperplasia (BPH), demonstrating long-term efficacy and tolerability. They improved symptoms, urinary flow, and reduced prostate volume, with effects typically observed 3-6 months after starting treatment. These drugs were particularly effective in men with larger prostates and higher PSA levels. However, they were associated with sexual dysfunction side effects, such as decreased libido, erectile dysfunction, and ejaculation dysfunction. The chapter also reviewed the development, efficacy, tolerability, and impact of 5ARIs on prostate cancer.
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