TLDR 5α-reductase inhibitors do not increase anaemia risk compared to α-blockers in men with BPH.
This study investigated the risk of anaemia in men with benign prostatic hyperplasia (BPH) using 5‐α reductase inhibitors (5αRIs) compared to α‐blockers. The cohort included 9,429 new users of 5αRIs and 9,429 matched new users of α‐blockers, with follow-up durations of 136 and 77 days, respectively. Anaemia rates were 37.3 per 100 person-years for 5αRIs users and 42.0 for α‐blocker users. The study concluded that 5αRIs did not increase the risk of anaemia compared to α‐blockers, with a hazard ratio of 0.95, indicating no significant difference in the risk of developing mild, moderate, or severe anaemia between the two groups.
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