Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization, and Comparative Analysis of Their In Vitro Wound Healing Potential

    May 2025 in “ International Journal of Molecular Sciences ”
    Patrícia Sousa, Bruna Lopes, Ana Catarina Sousa … Ana Colette Maurício
    Studysummary This study found that exosomes and secretome derived from rat hair follicle stem cells show promising potential for wound healing and tissue repair, demonstrating significant wound closure and suggesting their broader applicability in regenerative medicine.
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    Research cited in this study 13

    1. Human Hair Follicle Mesenchymal Stem Cell-Derived Exosome Attenuates UVB-Induced Photoaging Via The miR-125b-5p/TGF-β1/Smad Axis Biomaterials Research · 2024
    2. Hair Follicle Stem Cells Promote Epidermal Regeneration Under Expanded Condition Frontiers in physiology · 2024
    3. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata Cell Biology International · 2023
    4. P63: A Crucial Player In Epithelial Stemness Regulation Oncogene · 2023
    5. Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders Cells · 2023
    6. Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing Stem cell research & therapy · 2023
    7. Tp63-Expressing Adult Epithelial Stem Cells Cross Lineage Boundaries Revealing Latent Hairy Skin Competence Nature Communications · 2020
    8. Recent Advances in the Controlled Release of Growth Factors and Cytokines for Improving Cutaneous Wound Healing Frontiers in Cell and Developmental Biology · 2020
    9. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017
    10. Culture and Characterization of Rat Hair Follicle Stem Cells Cytotechnology · 2014
    11. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    12. Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells Stem Cells and Development · 2006
    13. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005