Synergistic Effects of Mesenchymal Stem Cell Secretome and Wnt10b on Hair Follicle Regeneration in a 3D Bioengineering Model: A Preclinical Study

    November 2025 in “ Stem Cell Research & Therapy
    Amir Bajouri, Nasser Aghdami, Mohammad Ali Nilforoushzadeh
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    TLDR The combination of certain stem cell secretions and Wnt10b helps regenerate hair follicles effectively.
    The study investigates the combined effects of PMSC-secretome and Wnt10b in a GelMA hydrogel scaffold for hair follicle regeneration. This combination was effective in promoting hair follicle biofabrication and successful hair formation in vivo. However, the in vivo component had a small sample size of 3 per group, highlighting the need for larger-scale studies to confirm these promising results.
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